Globally, it has been noted that 68% of women and 57% of men with mental health problems are parents (Royal College of Psychiatrists, 2016) and about 23–32% of patients admitted to mental health care are caring for children (Reupert, 2007). Children with severe parental mental illness are at greater risk of physical, mental, social, emotional and behavioral ill-health (Ramchandani & Stein, 2003), developmental difficulties (Reupert, 2007), educational under achievement (Gopfert, Webster, & Seeman, 2004), lower competency than their peers (Oyserman, Mowbray, Meares, & Firminger, 2000) and educational difficulties that arise from a complex interplay of genetic, environmental and psychosocial factors (Bee, et al., 2014). These issues may extend into adulthood as social or occupational dysfunction, poor self-esteem, increased mental health morbidities and substance abuse. When a biological parent or other relative has mental illness, then the probability of developing the same condition is higher (Mattejat & Remschmidt, 2008). An important political and public health concern at present is the improvement of lives of children with severe mentally ill parents (SCIE, 2012) Parental mental illness negatively affects the life of the children and the family (Falloon, 2003). The children of mentally ill parents have issues in different domains of their quality of life, depending upon the nature of parental mental illness, the overall health of the child and the cultural context. It is important to identify the major factors affecting quality of life of these children in order to find out their issues, needs and life priorities and to help them to have a better quality of life. This is an exploratory cross- sectional study employed to study the problems faced in various domains of quality of life among the children of mentally ill parents in Kochi, Kerala. The study was conducted in collaboration with the University of Melbourne, Australia in 2016. The sample consisted of 101 individuals who were experiencing a severe, enduring mental illness (Personality disorder, Bipolar affective disorder, Major depressive disorder, Schizophrenia and others) and having children less than 18-year-old. in Ernakulam, India. The major areas focused in the study include the physical, psychological, social and economic wellbeing and the academic functioning of the children with parental mental illness. The study had also found the immediate, short term and long term needs of those children in order to enhance their QOL and wellbeing.